The Cordon ONCO target combines next-generation sequencing (NGS) with comprehensive molecular pathology case review and additional testing as needed. 
NGS analysis covers SNP, insertion and deletion (SNP_In_Del) as well as copy number variation (CNV). Our expert pathology case review will determine complementary IHC, FISH, and molecular assays to be performed in addition to NGS for a fully customized report. 
Method: NGS & Pathology testing 
Gene tested: SNP_In_Del: ABL1, AKT1, AKT2, AKT3, ALK, APC, ARAF, ARID1A, ARID1B, AR, ATM, ATRX, ATR, AXIN1, BARD1, BCL2, BRAF, BRCA1, BRCA2, BRIP1, BTK, CCND1, CCNE1, CD274, CDK12, CDK4, CDK6, CDKN1B, CDKN2A, CHD1, CHEK1, CHEK2, CIC, CSF1R, CTNNB1, EGFR, EPCAM, ERBB2, ERBB3, ERBB4, ESR1, EZH2, FANCD2, FANCL, FAT1, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GNA11, GNAQ, GNAS, HIF1A, HRAS, IDH1, IDH2, IGF1R, JAK2, JAK3, KEAP1, KIT, KMT2C, KRAS, MAP2K1, MAP2K2, MAPK1, MDM2, MET, MLH1, MLH3, MRE11, MSH2, MSH3, MSH6, MTOR, MYC, NBN, NF1, NF2, NOTCH1, NPM1, NRAS, NRG1, NSD1, NTRK1, NTRK2, NTRK3, PALB2, PDGFRA, PDGFRB, PIK3CA, PIK3R1, PMS1, PMS2, POLD1, POLE, PPP2R2A, PTCH1, PTEN, PTPN11, RAD50, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RB1, RET, ROS1 , RUNX1, SMAD4, SMARCA2, SMARCA4, SMO, SPOP, STK11, TERT, TP53, TSC1, TSC2, TWIST1, VHL, XRCC2, ZEB1 
CNV: AR, CD274, CDKN2A, EGFR, ERBB2, ERBB3, FGFR2, KRAS, MET, PIK3CA, PTEN 
Sensitivity: ≥ 99% 
Specificity: 99.99% 
Mean Coverage: >1000x 
Turnaround Time: 10 business days or less